Journal article
Effects of lithium and valproate on amphetamineinduced oxidative stress generation in an animal model of mania
Abstract
OBJECTIVE: Previous studies have suggested that oxidative stress may play a role in the pathophysiology of bipolar disorder (BD). Moreover, recent studies indicate that lithium and valproate exert neuroprotective effects against oxidative stress. We studied the effects of the mood stabilizers lithium and valproate on amphetamine-induced oxidative stress in an animal model of mania.
METHODS: In the first model (reversal treatment), adult male …
Authors
Frey BN; Valvassori SS; Réus GZ; Martins MR; Petronilho FC; Bardini K; Dal-Pizzol F; Kapczinski F; Quevedo J
Journal
Journal of Psychiatry and Neuroscience, Vol. 31, No. 5, pp. 326–332
Publication Date
September 2006
DOI
10.1503/jpn.0637
ISSN
1180-4882
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AnimalsAnticonvulsantsAntimanic AgentsBipolar DisorderCatalaseDextroamphetamineDisease Models, AnimalDrug InteractionsHippocampusLipid PeroxidationLithium CarbonateMaleMotor ActivityOxidative StressPrefrontal CortexProtein CarbonylationRatsRats, WistarSuperoxide DismutaseThiobarbituric Acid Reactive SubstancesValproic Acid