Serum levels of brain-derived neurotrophic factor in schizophrenia on a hypocaloric diet Journal Articles uri icon

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  • Dietary factors influence BDNF in animal studies, but there is no comparable data in clinical populations. We examined the effect of a dietary intervention on BDNF serum levels in 67 DSM-IV schizophrenic outpatients (51 males and 16 females). Two groups were assessed in a cross-sectional study: one on a hypocaloric diet (HD) and the other not on a hypocaloric diet. Weight, height and BMI data were collected concurrently with 5-ml blood sampling of each subject. BDNF levels were measured with a sandwich-ELISA. The blood sample was obtained a minimum of one month after the exposure to dietary intervention. Serum BDNF levels were significantly higher in patients on the HD (p=0.023). Additional research examining the interaction among patterns of nutritional food behavior and underlying physiopathology may result in insights upon which evidence-based decisions regarding dietary interventions can be made in people identified with major psychiatric disorders, such as schizophrenia.


  • Guimarães, Lísia Rejane
  • Jacka, Felice N
  • Gama, Clarissa Severino
  • Berk, Michael
  • Leitão-Azevedo, Carmen Lúcia
  • Belmonte de Abreu, Martha Guerra
  • Lobato, Maria Inês
  • Andreazza, Ana Cristina
  • Ceresér, Keila Maria
  • Kapczinski, Flavio
  • Belmonte-de-Abreu, Paulo

publication date

  • August 2008