Journal article
Dose and polymorphic genes xrcc1, xrcc3, gst play a role in the risk of developing erythema in breast cancer patients following single shot partial breast irradiation after conservative surgery
Abstract
BackgroundTo evaluate the association between polymorphisms involved in DNA repair and oxidative stress genes and mean dose to whole breast on acute skin reactions (erythema) in breast cancer (BC) patients following single shot partial breast irradiation (SSPBI) after breast conservative surgery.Materials and MethodsAcute toxicity was assessed using vers.3 criteria. single nucleotides polymorphisms(SNPs) in genes: XRCC1(Arg399Gln/Arg194Trp), …
Authors
Falvo E; Strigari L; Citro G; Giordano C; Arcangeli S; Soriani A; D'Alessio D; Muti P; Blandino G; Sperduti I
Journal
BMC Cancer, Vol. 11, No. 1,
Publisher
Springer Nature
Publication Date
December 2011
DOI
10.1186/1471-2407-11-291
ISSN
1471-2407
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AgedAged, 80 and overBreast NeoplasmsDNA RepairDNA-Binding ProteinsErythemaFemaleGenetic Predisposition to DiseaseGenotypeGlutathione S-Transferase piGlutathione TransferaseHumansLogistic ModelsMiddle AgedMultivariate AnalysisOxidative StressPolymorphism, Single NucleotideProspective StudiesRad51 RecombinaseRadiotherapy DosageRadiotherapy, ConformalRisk FactorsX-ray Repair Cross Complementing Protein 1