Journal article
Intestinal SR-BI is upregulated in insulin-resistant states and is associated with overproduction of intestinal apoB48-containing lipoproteins
Abstract
Intestinal lipid dysregulation is a common feature of insulin-resistant states. The present study investigated alterations in gene expression of key proteins involved in the active absorption of dietary fat and cholesterol in response to development of insulin resistance. Studies were conducted in two diet-induced animal models of insulin resistance: fructose-fed hamster and high-fat-fed mouse. Changes in the mRNA abundance of lipid …
Authors
Hayashi AA; Webb J; Choi J; Baker C; Lino M; Trigatti B; Trajcevski KE; Hawke TJ; Adeli K
Journal
AJP Gastrointestinal and Liver Physiology, Vol. 301, No. 2, pp. g326–g337
Publisher
American Physiological Society
Publication Date
August 2011
DOI
10.1152/ajpgi.00425.2010
ISSN
0193-1857
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
ATP Binding Cassette Transporter, Subfamily G, Member 5ATP Binding Cassette Transporter, Subfamily G, Member 8ATP-Binding Cassette TransportersAnimalsApolipoprotein B-48CD36 AntigensCricetinaeDietary FatsDuodenumDyslipidemiasFastingFatty Acid Transport ProteinsFructoseGene ExpressionIleumInsulinInsulin ResistanceIntestinal MucosaJejunumLipoproteinsMaleMembrane Transport ProteinsMesocricetusMiceMice, Inbred C57BLModels, AnimalPostprandial PeriodRNA, MessengerUp-Regulation