Journal article
Underactivation of the adiponectin–adiponectin receptor 1 axis in clear cell renal cell carcinoma: implications for progression
Abstract
Abstract
Energy-sensing pathways, normally coordinated by 5′ AMP-activated protein kinase (AMPK), are dysregulated in renal cell carcinoma (RCC). Obesity can accentuate the pre-existing pro-tumorigenic metabolic machinery in RCC cells through its associated obesogenic hormonal milieu, characterized by lower circulating levels of adiponectin. In RCC patients, low adiponectin levels associate clinically with more aggressive disease. We …
Authors
Kleinmann N; Duivenvoorden WCM; Hopmans SN; Beatty LK; Qiao S; Gallino D; Lhotak S; Daya D; Paschos A; Austin RC
Journal
Clinical & Experimental Metastasis, Vol. 31, No. 2, pp. 169–183
Publisher
Springer Nature
Publication Date
2 2014
DOI
10.1007/s10585-013-9618-1
ISSN
0262-0898