Journal article
Adenoviral-Mediated Gene Transfer of Interleukin-6 in Rat Lung Enhances Antiviral Immunoglobulin A and G Responses in Distinct Tissue Compartments
Abstract
The effect of IL-6 transgene expression following lung gene transfer on anti-adenovirus humoral responses of immunoglobulin (Ig) G and A both in the lung and peripheral blood was investigated. Lung infection by a control adenovirus caused an increased level of circulating anti-adenoviral IgG antibodies. However, the magnitude of this response was many times higher in the peripheral blood of rats receiving an adenovirus engineered to express …
Authors
Xing Z; Braciak T; Chong D; Feng X; Schroeder J-A; Gauldie J
Journal
Biochemical and Biophysical Research Communications, Vol. 258, No. 2, pp. 332–335
Publisher
Elsevier
Publication Date
May 1999
DOI
10.1006/bbrc.1999.0644
ISSN
0006-291X