Journal article
A Glycemic Threshold Above Which the Improvement of β-Cell Function and Glycemia in Response to Insulin Therapy Is Amplified in Early Type 2 Diabetes: The Reversal of Glucotoxicity.
Abstract
OBJECTIVE: Alleviation of unrecognized glucotoxicity, with resultant recovery of β-cell function, could amplify the glucose-lowering effect of pharmacotherapy and contribute to the variable therapeutic response observed among patients with type 2 diabetes (T2D). However, clinical evidence supporting this concept is lacking. Short-term intensive insulin therapy (IIT) can ameliorate glucotoxicity and improve β-cell function in early T2D. Thus, …
Authors
Retnakaran R; Pu J; Ye C; Emery A; Harris SB; Reichert SM; Gerstein HC; McInnes N; Kramer CK; Zinman B
Journal
Diabetes Care, Vol. 47, No. 11, pp. 2017–2023
Publisher
American Diabetes Association
Publication Date
November 1, 2024
DOI
10.2337/dc24-1375
ISSN
0149-5992