Journal article
Healthy First-Degree Relatives From Multiplex Families vs Simplex Families Have Higher Subclinical Intestinal Inflammation, a Distinct Fecal Microbial Signature, and Harbor a Higher Risk of Developing Crohn’s Disease
Abstract
BACKGROUND & AIMS: Unaffected first-degree relatives (FDRs) from families with ≥2 affected FDRs with Crohn's disease (CD, multiplex families) have a high risk of developing CD, although the underlying mechanisms driving this risk are poorly understood. We aimed to identify differences in biomarkers between FDRs from multiplex vs simplex families and investigate the risk of future CD onset accounting for potential confounders.
METHODS: We …
Authors
Olivera PA; Martinez-Lozano H; Leibovitzh H; Xue M; Neustaeter A; Espin-Garcia O; Xu W; Madsen KL; Guttman DS; Bernstein CN
Journal
Gastroenterology, Vol. 168, No. 1, pp. 99–110.e2
Publisher
Elsevier
Publication Date
January 2025
DOI
10.1053/j.gastro.2024.08.031
ISSN
0016-5085