Journal article
Linkage analysis of 26 Canadian breast and breast-ovarian cancer families
Abstract
We have examined 26 Canadian families with hereditary breast or ovarian cancer for linkage to markers flanking the BRCA1 gene on chromosome 17q12–q21. Of the 15 families that contain cases of ovarian cancer, 94% were estimated to be linked to BRCA1. In contrast, there was no overall evidence of linkage in the group of 10 families with breast cancer without ovarian cancer. A genetic recombinant in a breast-ovarian cancer family indicates a …
Authors
Tonin P; Moslehi R; Green R; Rosen B; Cole D; Boyd N; Cutler C; Margolese R; Carter R; McGillivray B
Journal
Human Genetics, Vol. 95, No. 5, pp. 545–550
Publisher
Springer Nature
Publication Date
May 1995
DOI
10.1007/bf00223867
ISSN
0340-6717