Linkage analysis of 26 Canadian breast and breast-ovarian cancer families Journal Articles uri icon

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  • We have examined 26 Canadian families with hereditary breast or ovarian cancer for linkage to markers flanking the BRCA1 gene on chromosome 17q12-q21. Of the 15 families that contain cases of ovarian cancer, 94% were estimated to be linked to BRCA1. In contrast, there was no overall evidence of linkage in the group of 10 families with breast cancer without ovarian cancer. A genetic recombinant in a breast-ovarian cancer family indicates a placement of BRCA1 telomeric to D17S776, and helps to define the region of assignment of the cancer susceptibility gene. Other cancers of interest that appeared in the BRCA1-linked families included primary peritoneal cancer, cancer of the fallopian tube, and malignant melanoma.


  • Tonin, Patricia
  • Moslehi, Roxanna
  • Green, Roger
  • Rosen, Barry
  • Cole, David
  • Boyd, Norman
  • Cutler, Corey
  • Margolese, Richard
  • Carter, Ronald
  • McGillivray, Barbara
  • Ives, Elizabeth
  • Labrie, Fernand
  • Gilchrist, Dawna
  • Morgan, Kenneth
  • Simard, Jacques
  • Narod, StevenA

publication date

  • May 1995

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