Structural Basis for the Biological Effects of Pr(III) Ions: Alteration of Cell Membrane Permeability Journal Articles uri icon

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abstract

  • The biological effects of rare-earth ions on the organism have been studied using Pr3+ as a probe ion and Escherichia coli cell as a target. Atomic force microscopy (AFM) observation of the surface of E. coli cells shows that the presence of Pr3+ substantially changes the structure of the outer membrane. By induced coupled plasma-mass spectrometry (ICP-MS), more Cu2+ was found in the cells grown in the presence of Pr3+, indicating changes of cell permeability. Using energy dispersive X-ray spectroscopy (EDX), Ca2+ is found on the outer surface of the original cell. It is proposed that Pr3+ can replace Ca2+ from the binding sites because of their close ionic radii and similar ligand speciality.

authors

  • Peng, Liu
  • Weiying, Zhang
  • Xi, Li
  • Yi, Liu

publication date

  • October 2, 2007