Journal article
Type 2–polarized memory B cells hold allergen-specific IgE memory
Abstract
Allergen-specific immunoglobulin E (IgE) antibodies mediate pathology in diseases such as allergic rhinitis and food allergy. Memory B cells (MBCs) contribute to circulating IgE by regenerating IgE-producing plasma cells upon allergen encounter. Here, we report a population of type 2-polarized MBCs defined as CD23hi, IL-4Rαhi, and CD32low at both the transcriptional and surface protein levels. These MBC2s are enriched in IgG1- and …
Authors
Koenig JFE; Knudsen NPH; Phelps A; Bruton K; Hoof I; Lund G; Libera DD; Lund A; Christensen LH; Glass DR
Journal
Science Translational Medicine, Vol. 16, No. 733,
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
February 7, 2024
DOI
10.1126/scitranslmed.adi0944
ISSN
1946-6234