Voluntary physical activity and leucine correct impairments in muscle protein synthesis in partially pancreatectomised rats

Aims/hypothesisPoorly controlled type 1 diabetes mellitus can cause reduced skeletal muscle mass and weakness during adolescence, which may affect long-term management of the disease. The aim of this study was to determine whether regular voluntary physical activity and leucine feeding restore rates of protein synthesis and deficits in skeletal muscle mass in a young, hypoinsulinaemic/hyperglycaemic rat model of diabetes.MethodsFour-week-old …