Journal article
The effect of E1 mutations on biochemical transformation by an adenovirus carrying the herpes simplex virus thymidine kinase gene in region E3
Abstract
A series of human adenovirus type 5 (Ad5) vectors has been constructed in which a vector containing the human herpes simplex virus thymidine kinase (TK) gene has been recombined with several Ad5 early region 1 (E1) mutants. The resulting viruses were used to study host-virus interactions in TK- rat cells and to examine the importance of E1 functions in a biochemical transformation assay. One of the most important parameters affecting …
Authors
Wilson GM; Graham FL
Journal
Virus Research, Vol. 13, No. 1, pp. 29–44
Publisher
Elsevier
Publication Date
May 1989
DOI
10.1016/0168-1702(89)90085-3
ISSN
0168-1702