Journal article
Inhibition of Actomyosin ATPase by High Concentrations of 5-Hydroxytryptamine. Possible Basis of Lesion in 5HT-Induced Experimental Myopathy
Abstract
The effect of 5-hydroxytryptamine (5HT) on the ATPase activity and sulphydryl group reactivity of mammalian skeletal muscle actomyosin has been studied. 5HT inhibited the Mg2+-activated but not the Ca2+-activated ATPase activity of actomyosin. It slightly activated myosin ATPase. The sulphydryl groups of actomyosin reacting with 5,5'-dithiobis-(2-nitrobenzoic acid) were blocked by concentrations of 5HT which inhibited the Mg2+-activated ATPase. …
Authors
Mothersill C; Heffron JJA; McLoughlin JV
Journal
Enzyme and Protein, Vol. 21, No. 6, pp. 481–487
Publisher
Karger Publishers
Publication Date
1976
DOI
10.1159/000458900
ISSN
1019-6773