Brain age in mood and psychotic disorders: a systematic review and meta‐analysis Journal Articles uri icon

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  • AbstractObjectiveTo evaluate whether accelerated brain aging occurs in individuals with mood or psychotic disorders.MethodsA systematic review following PRISMA guidelines was conducted. A meta‐analysis was then performed to assess neuroimaging‐derived brain age gap in three independent groups: (1) schizophrenia and first‐episode psychosis, (2) major depressive disorder, and (3) bipolar disorder.ResultsA total of 18 papers were included. The random‐effects model meta‐analysis showed a significantly increased neuroimaging‐derived brain age gap relative to age‐matched controls for the three major psychiatric disorders, with schizophrenia (3.08; 95%CI [2.32; 3.85]; p < 0.01) presenting the largest effect, followed by bipolar disorder (1.93; [0.53; 3.34]; p < 0.01) and major depressive disorder (1.12; [0.41; 1.83]; p < 0.01). The brain age gap was larger in older compared to younger individuals.ConclusionIndividuals with mood and psychotic disorders may undergo a process of accelerated brain aging reflected in patterns captured by neuroimaging data. The brain age gap tends to be more pronounced in older individuals, indicating a possible cumulative biological effect of illness burden.


  • Ballester, Pedro L
  • Romano, Maria T
  • de Azevedo Cardoso, Taiane
  • Hassel, Stefanie
  • Strother, Stephen C
  • Kennedy, Sidney H
  • Frey, Benicio

publication date

  • January 2022