Journal article
Relation between clopidogrel active metabolite levels and different platelet aggregation methods in patients receiving clopidogrel and aspirin
Abstract
Clopidogrel is a prodrug that undergoes bioconversion via cytochrome P450 system to form an active metabolite (AM) that binds to the platelet ADP receptor. The antiplatelet effect of clopidogrel is commonly assessed by measuring the aggregatory response to 5 μM ADP by light transmission aggregation (LTA) or multiple electrode aggregometry (MEA) or by the vasodilator-stimulated phosphoprotein platelet reactivity index (VASP-PRI). To determine …
Authors
Liang Y; Johnston M; Hirsh J; Pare G; Li C; Mehta S; Teo KK; Sloane D; Yi Q; Zhu J
Journal
Journal of Thrombosis and Thrombolysis, Vol. 34, No. 4, pp. 429–436
Publisher
Springer Nature
Publication Date
11 2012
DOI
10.1007/s11239-012-0762-2
ISSN
0929-5305