Journal article
Overexpression of poly(ADP-ribose) polymerase promotes cell cycle arrest and inhibits neutrophilic differentiation of NB4 acute promyelocytic leukemia cells.
Abstract
The t(15;17) translocation causes a disruption of the retinoic acid receptor alpha (RAR-alpha) and allows for the expression of the PML-RAR alpha fusion protein considered to be responsible for the differentiation block in acute promyelocytic leukemia (APL). Patients being treated with all-trans retinoic acid (ATRA) undergo remission due to the differentiation of leukemic cells to functional neutrophils but relapse due to subsequent ATRA …
Authors
Bhatia M; Kirkland JB; Meckling-Gill KA
Journal
Molecular Cancer Research, Vol. 7, No. 1, pp. 91–100
Publication Date
January 1996
ISSN
1541-7786