Journal article
IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro
Abstract
Distinctive properties of stem cells are not autonomously achieved, and recent evidence points to a level of external control from the microenvironment. Here, we demonstrate that self-renewal and pluripotent properties of human embryonic stem (ES) cells depend on a dynamic interplay between human ES cells and autologously derived human ES cell fibroblast-like cells (hdFs). Human ES cells and hdFs are uniquely defined by insulin-like growth …
Authors
Bendall SC; Stewart MH; Menendez P; George D; Vijayaragavan K; Werbowetski-Ogilvie T; Ramos-Mejia V; Rouleau A; Yang J; Bossé M
Journal
Nature, Vol. 448, No. 7157, pp. 1015–1021
Publisher
Springer Nature
Publication Date
August 2007
DOI
10.1038/nature06027
ISSN
0028-0836