Scholarly Works

Characterization of human embryonic stem cells...

Journal article

Characterization of human embryonic stem cells with features of neoplastic progression

Abstract

Werbowetski-Ogilvie et al. show that cultured human embryonic stem (hES) cells that appear normal may in fact be partially transformed. Two such lines are found to have aberrant growth and differentiation properties and submicroscopic chromosomal abnormalities.

Authors

Werbowetski-Ogilvie TE; Bossé M; Stewart M; Schnerch A; Ramos-Mejia V; Rouleau A; Wynder T; Smith M-J; Dingwall S; Carter T

Journal

Nature Biotechnology, Vol. 27, No. 1, pp. 91–97

Publisher

Springer Nature

Publication Date

January 25, 2009

DOI

10.1038/nbt.1516

ISSN

1087-0156

Associated Experts

Douglas Robert Boreham

Adjunct Professor, Faculty of Science

Mick Bhatia

Professor, Faculty of Health Sciences

Labels

Fields of Research (FoR)

3206 Medical Biotechnology 32 Biomedical and Clinical Sciences

Medical Subject Headings (MeSH)

Cell Differentiation Cell Line Cell Line, Tumor Chromosome Aberrations Comparative Genomic Hybridization Cytogenetics Disease Progression Embryonic Stem Cells Fibroblast Growth Factor 2 Genetic Techniques Humans Neoplasms Nucleic Acid Hybridization Phenotype Stem Cells

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