Journal article
Polypill with or without Aspirin in Persons without Cardiovascular Disease
Abstract
BACKGROUND: A polypill comprising statins, multiple blood-pressure-lowering drugs, and aspirin has been proposed to reduce the risk of cardiovascular disease.
METHODS: Using a 2-by-2-by-2 factorial design, we randomly assigned participants without cardiovascular disease who had an elevated INTERHEART Risk Score to receive a polypill (containing 40 mg of simvastatin, 100 mg of atenolol, 25 mg of hydrochlorothiazide, and 10 mg of ramipril) or …
Authors
Yusuf S; Joseph P; Dans A; Gao P; Teo K; Xavier D; López-Jaramillo P; Yusoff K; Santoso A; Gamra H
Journal
New England Journal of Medicine, Vol. 384, No. 3, pp. 216–228
Publisher
Massachusetts Medical Society
Publication Date
January 21, 2021
DOI
10.1056/nejmoa2028220
ISSN
0028-4793