Journal article
Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Syndrome
Abstract
BACKGROUND: Gnotobiotic mice colonized with microbiota from patients with irritable bowel syndrome (IBS) and comorbid anxiety (IBS+A) display gut dysfunction and anxiety-like behavior compared to mice colonized with microbiota from healthy volunteers. Using this model, we tested the therapeutic potential of the probiotic yeast Saccharomyces boulardii strain CNCM I-745 (S. bou) and investigated underlying mechanisms.
METHODS: Germ-free Swiss …
Authors
Constante M; De Palma G; Lu J; Jury J; Rondeau L; Caminero A; Collins SM; Verdu EF; Bercik P
Journal
Neurogastroenterology & Motility, Vol. 33, No. 3,
Publisher
Wiley
Publication Date
March 2021
DOI
10.1111/nmo.13985
ISSN
1350-1925