MEG analysis of "theory of mind" in emotional vignettes comprehension.

OBJECTIVE: Several studies suggested that an impaired "theory of mind" might play a key role in psychiatric disorders, such as autism and schizophrenia. Medial frontal lobe lesions of the right frontal lobe were reported to impair this ability. The aim of our study was to locate areas of the brain associated with the process of "theory of mind" in normal subjects. METHODS: In order to index the activity of brain areas related to "theory of mind" reasoning in sixteen normal adults, we administered an emotional ("happy", "sad", "angry" and "neutral") vignettes comprehension task during magnetoencephalography (MEG) recordings and analyzed these data by using SAM (synthetic aperture magnetometry), SPM99 and the permutation method. Subjects were presented with eight different videotaped social situations (each emotion has two vignettes) and were asked to indicate which emotion they represented. RESULTS: Statistically significant activation in the comparison of "happy"-"sad" and "angry"-"sad" was observed in the bilateral medial prefrontal cortices in the alpha frequency band. There were no significant differences in comparisons of each type of emotional vignette to the neutral vignettes, "happy"-"angry" comparison, and male-female comparisons. There was no significant difference in other frequency bands. CONCLUSION: This result suggests that bilateral medial prefrontal cortex are involved in the comprehension of emotional states of others.