Journal article
Active metabolite concentration of clopidogrel in patients taking different doses of aspirin: results of the interaction trial
Abstract
BACKGROUND: The CURRENT-OASIS-7 and PLATO trials suggest that the benefit of clopidogrel is influenced by the dose of aspirin.
OBJECTIVE: To explore a potential pharmacokinetic interaction between aspirin and clopidogrel, and determinants of clopidogrel active metabolite (AM) levels.
Authors
Liang Y; Hirsh J; Weitz JI; Sloane D; Gao P; Pare G; Zhu J; Eikelboom JW
Journal
Journal of Thrombosis and Haemostasis, Vol. 13, No. 3, pp. 347–352
Publisher
Elsevier
Publication Date
3 2015
DOI
10.1111/jth.12829
ISSN
1538-7933