Journal article
Warfarin and Aspirin in Patients with Heart Failure and Sinus Rhythm
Abstract
BACKGROUND: It is unknown whether warfarin or aspirin therapy is superior for patients with heart failure who are in sinus rhythm.
METHODS: We designed this trial to determine whether warfarin (with a target international normalized ratio of 2.0 to 3.5) or aspirin (at a dose of 325 mg per day) is a better treatment for patients in sinus rhythm who have a reduced left ventricular ejection fraction (LVEF). We followed 2305 patients for up to 6 …
Authors
Homma S; Thompson JLP; Pullicino PM; Levin B; Freudenberger RS; Teerlink JR; Ammon SE; Graham S; Sacco RL; Mann DL
Journal
New England Journal of Medicine, Vol. 366, No. 20, pp. 1859–1869
Publisher
Massachusetts Medical Society
Publication Date
May 17, 2012
DOI
10.1056/nejmoa1202299
ISSN
0028-4793