Journal article
Peritoneal morphological and functional changes associated with platelet-derived growth factor B
Abstract
BACKGROUND: Morphological changes associated with long-term peritoneal dialysis (PD) include increased vascular surface area due to angiogenesis, submesothelial fibrosis and epithelial mesenchymal transition. Platelet-derived growth factor (PDGF) has been associated with all of these phenomena, and is a prototypical 'response to injury' growth factor.
METHODS: Rats received an intraperitoneal injection of adenoviral vector expressing PDGF-B. At …
Authors
Cina D; Patel P; Bethune JC; Thoma J; Rodriguez-Lecompte JC; Hoff CM; Liu L; Margetts PJ
Journal
Nephrology Dialysis Transplantation, Vol. 24, No. 2, pp. 448–457
Publisher
Oxford University Press (OUP)
Publication Date
February 2009
DOI
10.1093/ndt/gfn498
ISSN
0931-0509
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdenoviridaeAnimalsCollagenCollagen Type IEpitheliumGene ExpressionGenes, sisGenetic VectorsHumansMesodermNeovascularization, PathologicPeritoneal DialysisPeritoneumPlasminogen Activator Inhibitor 1Polymerase Chain ReactionProto-Oncogene Proteins c-sisRNA, MessengerRatsRats, Sprague-DawleyRecombinant ProteinsTransforming Growth Factor beta1