Journal article
Methodology and pharmacological analysis of effects of uterotonic compounds in human myometrium in vitro
Abstract
OBJECTIVE: The methodology used to evaluate contractile effects of uterotonic agents in human myometrium in vitro varies. The are no studies evaluating the reliability of these commonly used techniques.
STUDY DESIGN: Myometrial strips (n=72) were exposed to 3 known uterotonic agents: oxytocin, U46619, and phenylephrine. The negative log of the molar concentration of the agonist that produces a half-maximal response (pEC50) and maximal response …
Authors
Crankshaw DJ; Morrison JJ
Journal
American Journal of Obstetrics and Gynecology, Vol. 205, No. 2, pp. 155.e1–155.e6
Publisher
Elsevier
Publication Date
August 2011
DOI
10.1016/j.ajog.2011.03.014
ISSN
0002-9378