Journal article
Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial
Abstract
BACKGROUND: Nerinetide, an eicosapeptide that interferes with post-synaptic density protein 95, is a neuroprotectant that is effective in preclinical stroke models of ischaemia-reperfusion. In this trial, we assessed the efficacy and safety of nerinetide in human ischaemia-reperfusion that occurs with rapid endovascular thrombectomy in patients who had an acute ischaemic stroke.
METHODS: For this multicentre, double-blind, randomised, …
Authors
Hill MD; Goyal M; Menon BK; Nogueira RG; McTaggart RA; Demchuk AM; Poppe AY; Buck BH; Field TS; Dowlatshahi D
Journal
The Lancet, Vol. 395, No. 10227, pp. 878–887
Publisher
Elsevier
Publication Date
3 2020
DOI
10.1016/s0140-6736(20)30258-0
ISSN
0140-6736