selected scholarly activity
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chapters
- The Neutrophil and Inflammation. 777-784. 2020
- The Neutrophil and Inflammation. 777-784. 2009
- Liberation from Mechanical Ventilation in Acutely Brain-injured Patients. 486-493. 2007
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conferences
- Assessing differences in start-up between a pilot and main RCT in the ICU: The CYCLE international multicentre rehabilitation study. Trials. 2019
- Tu1068 Diarrhea in the Intensive Care Unit: Epidemiology (The DICE Study). Gastroenterology. S832-S832. 2016
- Heat Shock Protein 90 (hsp90) Stabilizes A Molecular Complex Of Caspase-8 And Toll-Like Receptor-4 (tlr-4) To Prolong Polymorphonuclear Neutrophil (pmn) Survival And Regulate Respiratory Burst Activity. American Journal of Respiratory and Critical Care Medicine. 2016
- Targeted Deletion Of Dj-1 Attenuates Morbidity And Mortality In Experimental Sepsis Through Enhanced Autophagic Bacterial Clearance. American Journal of Respiratory and Critical Care Medicine. 2014
- CASPASE-8 TYROSINE PHOSPHORYLATION IS A POTENTIAL MECHANISM OF INCREASED NEUTROPHIL SURVIVAL IN SEPTIC PATIENTS. Intensive Care Medicine. S501-S501. 2013
- Fine pitch “NCF-type compliant-bumped COG”. 2007 International Microsystems, Packaging, Assembly and Circuits Technology. 14-+. 2007
- Carbon nanotube optoelectronics. Physica Status Solidi (B): Basic Research. 3197-3203. 2006
- Effectiveness of bone mineral density for predicting osteoporotic fractures in a large clinical population.. Journal of Bone and Mineral Research. S169-S169. 2006
- Fracture risk and site-discordance: The total hip dominates other sites.. Journal of Bone and Mineral Research. S16-S16. 2006
- Greater number of osteoporotic sites and fracture risk: Regression to the minimum.. Journal of Bone and Mineral Research. S17-S17. 2006
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journal articles
- Factors influencing community intensive care unit research participation: a qualitative descriptive study.. Canadian Journal of Anaesthesia. 2024
- Frequency of Screening and Spontaneous Breathing Trial Techniques: A Randomized Clinical Trial.. Journal of the American Medical Association (JAMA). 332:1808-1821. 2024
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Canadian intensive care unit nurses' responses to moral distress during the
COVID ‐19 pandemic, and their recommendations for mitigative interventions. Journal of Advanced Nursing. 80:4974-4988. 2024 - Important features of hospitals, intensive care unit waiting rooms, and patient care rooms: perspectives of intensive care unit visitors.. Canadian Journal of Anaesthesia. 1-8. 2024
- Research priorities for the study of atrial fibrillation during acute and critical illness: recommendations from the Symposium on Atrial Fibrillation in Acute and Critical Care.. BMC Proceedings. 18:23. 2024
- Early In-Bed Cycle Ergometry With Critically Ill, Mechanically Ventilated Patients: Statistical Analysis Plan for CYCLE (Critical Care Cycling to Improve Lower Extremity Strength), an International, Multicenter, Randomized Clinical Trial.. JMIR Research Protocols. 13:e54451. 2024
- The research activities of Ontario's large community hospitals: an updated scoping review.. BMC Health Services Research. 24:1137. 2024
- Effects of Losartan on Patients Hospitalized for Acute Coronavirus Disease 2019: A Randomized Controlled Trial. Clinical Infectious Diseases. 79:615-625. 2024
- Protocol for a systematic review and meta-analysis investigating the impact of continuous versus intermittent enteral feeding in critically ill patients.. Systematic Reviews. 13:239. 2024
- Stress Ulcer Prophylaxis during Invasive Mechanical Ventilation. New England Journal of Medicine. 391:9-20. 2024
- COVID-19 Immunologic Antiviral Therapy With Omalizumab (CIAO)—a Randomized Controlled Clinical Trial. Open Forum Infectious Diseases. 11:ofae102. 2024
- Modelling the potential increase in eligible participants in clinical trials with inclusion of community intensive care unit patients in Alberta, Canada: a decision tree analysis. Canadian Journal of Anaesthesia. 71:390-399. 2024
- Barriers to participation in biosampling-based translational research: A cross-sectional survey of Canadian critical care researchers. PLoS ONE. 19:e0303304-e0303304. 2024
- Effect of omalizumab on inflammatory markers in COVID-19: an exploratory analysis of the COVID-19 immunologic antiviral therapy with omalizumab (CIAO) trial.. Frontiers in Medicine. 11:1437322. 2024
- Impact of sample processing delays on plasma markers of inflammation, chemotaxis, cell death, and blood coagulation.. PLoS ONE. 19:e0311921. 2024
- The impact of COVID-19 workload on psychological distress amongst Canadian intensive care unit healthcare workers during the 1st wave of the COVID-19 pandemic: A longitudinal cohort study. PLoS ONE. 19:e0290749-e0290749. 2024
- Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care. Journal of the American Medical Association (JAMA). 330:1872-1872. 2023
- Frequency of screening and SBT Technique Trial—North American Weaning Collaboration (FAST-NAWC): an update to the protocol and statistical analysis plan. Trials. 24:626. 2023
- Proton pump inhibitors in critically ill mechanically ventilated patients with COVID-19: protocol for a substudy of the Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial. Trials. 24:561. 2023
- Critical Care Cycling to ImproveLowerExtremity Strength (CYCLE): protocol for an international, multicentre randomised clinical trial of early in-bed cycling for mechanically ventilated patients. BMJ Open. 13:e075685-e075685. 2023
- Definitions, rates and associated mortality of ICU-acquired pneumonia: A multicenter cohort study. Journal of Critical Care. 75:154284-154284. 2023
- Hospitalised COVID-19 outcomes are predicted by hypoxaemia and pneumonia phenotype irrespective of the timing of their emergence. BMJ Open. 12:e062453-e062453. 2022
- Wellness and Coping of Physicians Who Worked in ICUs During the Pandemic: A Multicenter Cross-Sectional North American Survey*. Critical Care Medicine. 50:1689-1700. 2022
- Academic and Community ICUs Participating in a Critical Care Randomized Trial: A Comparison of Patient Characteristics and Trial Metrics. Critical Care Explorations. 4:e0794-e0794. 2022
- Needs Assessment Survey Identifying Research Processes Which may be Improved by Automation or Artificial Intelligence: ICU Community Modeling and Artificial Intelligence to Improve Efficiency (ICU-Comma). Journal of Intensive Care Medicine. 37:1296-1304. 2022
- Research interrupted: applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation during critical illness affected by the COVID-19 pandemic. Trials. 23:735. 2022
- Effect of Awake Prone Positioning on Endotracheal Intubation in Patients With COVID-19 and Acute Respiratory Failure. Journal of the American Medical Association (JAMA). 327:2104-2104. 2022
- Remdésivir chez les patients hospitalisés pour la COVID-19 au Canada: essai clinique randomisé et contrôlé. CANADIAN MEDICAL ASSOCIATION JOURNAL. 194:E713-E723. 2022
- Diarrhea during critical illness: a multicenter cohort study. Intensive Care Medicine. 48:570-579. 2022
- How can we increase participation in pandemic research in Canada?. Canadian Journal of Anaesthesia. 69:293-297. 2022
- Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial. CANADIAN MEDICAL ASSOCIATION JOURNAL. 194:E242-E251. 2022
- Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial. Nature Medicine. 28:212-212. 2022
- Identification and Assessment of Strategies to Address Gender Inequity in the Specialty of Critical Care Medicine: A Scoping Review, Modified Consensus Process, and Stakeholder Meeting. Critical Care Explorations. 4:e0612-e0612. 2022
- Motivating factors, barriers and facilitators of participation in COVID-19 clinical research: A cross-sectional survey of Canadian community intensive care units. PLoS ONE. 17:e0266770-e0266770. 2022
- Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19. Nature Medicine. 28:53-58. 2022
- Impact of a multifaceted and multidisciplinary intervention on pain, agitation and delirium management in an intensive care unit: an experience of a Canadian community hospital in conducting a quality improvement project. BMJ quality improvement reports. 10:e001305-e001305. 2021
- Initiating and integrating a personalized end of life care project in a community hospital intensive care unit: A qualitative study of clinician and implementation team perspectives. Journal of Evaluation in Clinical Practice. 27:1281-1290. 2021
- Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial. Nature Medicine. 27:2012-2024. 2021
- Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients. Journal of the American Medical Association (JAMA). 326:1024-1024. 2021
- External validation of the 4C mortality score among COVID-19 patients admitted to hospital in Ontario, Canada: a retrospective study. Scientific Reports. 11:18638. 2021
- Twenty articles that critical care clinicians should read about COVID-19. Intensive Care Medicine. 47:337-341. 2021
- Characteristics and outcomes of patients with COVID-19 admitted to hospital and intensive care in the first phase of the pandemic in Canada: a national cohort study. CMAJ open. 9:E181-E188. 2021
- Incidence and Outcomes of Acute Kidney Injury in Patients Admitted to Hospital With COVID-19: A Retrospective Cohort Study. Canadian Journal of Kidney Health and Disease. 8:205435812110277-205435812110277. 2021
- Psychosocial distress amongst Canadian intensive care unit healthcare workers during the acceleration phase of the COVID-19 pandemic. PLoS ONE. 16:e0254708-e0254708. 2021
- Participation of more community hospitals in randomized trials of treatments for COVID-19 is needed. CANADIAN MEDICAL ASSOCIATION JOURNAL. 192:E555-E555. 2020
- Epigenetics of Sepsis. Critical Care Medicine. 48:745-756. 2020
- Canadian Critical Care Society clinical practice guideline: The use of vasopressin and vasopressin analogues in critically ill adults with distributive shock. Canadian Journal of Anaesthesia. 67:369-376. 2020
- Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness*. Critical Care Medicine. 48:142-150. 2020
- Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness.. Critical Care Medicine. 48:142-150. 2020
- Fostering community hospital research. CANADIAN MEDICAL ASSOCIATION JOURNAL. 191:E962-E966. 2019
- Mortality Risk Profiles for Sepsis: A Novel Longitudinal and Multivariable Approach. Critical Care Explorations. 1:e0032-e0032. 2019
- Diarrhoea: interventions, consequences and epidemiology in the intensive care unit (DICE-ICU): a protocol for a prospective multicentre cohort study. BMJ Open. 9:e028237-e028237. 2019
- Qualitative descriptive study to explore nurses’ perceptions and experience on pain, agitation and delirium management in a community intensive care unit. BMJ Open. 9:e024328-e024328. 2019
- Impact of a multifaceted and multidisciplinary intervention on pain, agitation and delirium management in a Canadian community intensive care unit: a quality improvement study protocol. CMAJ open. 7:E430-E434. 2019
- It’s Time to Increase Community Hospital-Based Health Research. Academic Medicine. 92:727-727. 2017
- DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis. American Journal of Respiratory and Critical Care Medicine. 195:889-905. 2017
- Legionella pneumonia in the Niagara Region, Ontario, Canada: a case series. Journal of Medical Case Reports. 10:336. 2016
- Endotoxemia Following Multiple Trauma. Critical Care Medicine. 44:335-341. 2016
- Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src. PLoS ONE. 11:e0153946-e0153946. 2016
- Activated Neutrophils Induce Epithelial Cell Apoptosis Through Oxidant-Dependent Tyrosine Dephosphorylation of Caspase-8. American Journal of Pathology. 184:1030-1040. 2014
- Biomarkers in acute respiratory distress syndrome. Current Opinion in Critical Care. 20:47-55. 2014
- Sepsis and the innate-like response. Intensive Care Medicine. 40:249-251. 2014
- Acute refractory hypoxemia after chest trauma reversed by high-frequency oscillatory ventilation: a case report. Journal of Medical Case Reports. 7:186. 2013
- Regulation of apoptosis and priming of neutrophil oxidative burst by diisopropyl fluorophosphate. Journal of Inflammation. 7:32. 2010
- Discordance Between Physicians' Estimation of Patient Cardiovascular Risk and Use of Evidence-Based Medical Therapy. American Journal of Cardiology. 102:1142-1145. 2008
- Missed opportunities for the secondary prevention of cardiovascular disease in Canada. Canadian Journal of Cardiology. 23:1124-1130. 2007
- Generation and Expansion of Human CD4+CD25+ Regulatory T Cells with Indirect Allospecificity: Potential Reagents to Promote Donor-Specific Transplantation Tolerance. Transplantation. 82:1738-1743. 2006
- Adoptive Cell Therapy Using In Vitro Generated Human CD4+CD25+ Regulatory T Cells With Indirect Allospecificity to Promote Donor-Specific Transplantation Tolerance. Transplantation Proceedings. 38:3199-3201. 2006
- In vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation tolerance. International Immunopharmacology. 6:1879-1882. 2006
- In-vitro generation and characterisation of murine CD4+CD25+ regulatory T cells with indirect allospecificity. International Immunopharmacology. 6:1883-1888. 2006
- Comparison of fecal biota from specific pathogen free and feral mice. Anaerobe. 12:249-253. 2006
- Contemporary Management of Dyslipidemia in High-Risk Patients: Targets Still Not Met. American Journal of Medicine. 119:676-683. 2006
- Pediatric wrist buckle fractures: Should we just splint and go?. Canadian Journal of Emergency Medicine. 6:397-401. 2004
- Six-month outcomes of percutaneous transluminal coronary angioplasty in hypertensive patients: Results from the ROSETTA registry. American Heart Journal. 143:124-129. 2002
- Coronary stenting in diabetic patients: Results from the ROSETTA registry. American Heart Journal. 142:960-964. 2001