Journal article
Dual immunosuppression enhances vasomotor injury: Interactive effect between endothelin-1 and nitric oxide bioavailability
Abstract
OBJECTIVE: Cyclosporine A and corticosteroids are associated with many side effects, such as endothelial dysfunction and transplant vasculopathy. We examined the effects of cyclosporine A and hydrocortisone exposure on endothelial function of the rat thoracic aorta.
METHODS: Lewis rats were injected with cyclosporine A, hydrocortisone, cyclosporine A + hydrocortisone, or intraperitoneal saline daily for 2 weeks. Endothelial-dependent and …
Authors
Ramzy D; Tumiati LC; Tepperman E; Sheshgiri R; Jackman J; Badiwala M; Rao V
Journal
Journal of Thoracic and Cardiovascular Surgery, Vol. 135, No. 4, pp. 938–944
Publisher
Elsevier
Publication Date
April 2008
DOI
10.1016/j.jtcvs.2007.09.075
ISSN
0022-5223