Journal article
Effect of selective monoamine oxidase inhibition by clorgyline and deprenyl on the norepinephrine receptor-coupled adenylate cyclase system in rat cortex
Abstract
The consequences of selective monoamine oxidase (MAO) inhibition on the norepinephrine(NE)-sensitive adenylate cyclase system were determined in slices of rat cerebral cortex. The chronic administration of clorgyline, which selectively inhibited the activity of MAO-A, caused a significant decrease in the responsiveness of the noradrenergic cyclic AMP-generating system. The noradrenergic subsensitivity was accompanied by a significant decrease …
Authors
Mishra R; Gillespie DD; Youdim MBH; Sulser F
Journal
Psychopharmacology, Vol. 81, No. 3, pp. 220–223
Publisher
Springer Nature
Publication Date
October 1983
DOI
10.1007/bf00427265
ISSN
0033-3158