For the first time, an analytical modeling methodology is developed for fire sprinkler piping systems and used to generate seismic fragility parameters of these systems. The analytical model accounts for inelastic behavior constituents of the system, including: threaded joints, solid braces, hangers, and restrainers. The model incorporates a newly developed hysteresis model for threaded tee joints that is validated by the experimental results of several tee subassemblies. The modeling technique at the subsystem level is validated by using the experimental results of a sprinkler piping system. The methodology is used to obtain the seismic response of the fire sprinkler piping system of University of California, San Francisco Hospital under a suite of 96 artificially generated triaxial floor acceleration histories. After the component fragility parameters are obtained for the components of the system, three system-level damage states are defined, and a joint probabilistic seismic demand model is utilized to develop system fragility parameters.