Journal article
Endothelin-1, but not angiotensin II, induces afferent arteriolar myosin diphosphorylation as a potential contributor to prolonged vasoconstriction
Abstract
Bolus administration of endothelin-1 elicits long-lasting renal afferent arteriolar vasoconstriction, in contrast to transient constriction induced by angiotensin II. Vasoconstriction is generally evoked by myosin regulatory light chain (LC20) phosphorylation at Ser19 by myosin light chain kinase (MLCK), which is enhanced by Rho-associated kinase (ROCK)-mediated inhibition of myosin light chain phosphatase (MLCP). LC20 can be diphosphorylated …
Authors
Takeya K; Wang X; Kathol I; Loutzenhiser K; Loutzenhiser R; Walsh MP
Journal
Kidney International, Vol. 87, No. 2, pp. 370–381
Publisher
Elsevier
Publication Date
2 2015
DOI
10.1038/ki.2014.284
ISSN
0085-2538
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Angiotensin IIAnimalsArteriolesCalcium Channel BlockersCalcium SignalingDiltiazemEndothelin A Receptor AntagonistsEndothelin-1Models, CardiovascularMyosin Light ChainsMyosin-Light-Chain KinasePhosphorylationRatsRats, Sprague-DawleyReceptor, Endothelin BSignal TransductionVasoconstrictionrho-Associated Kinases