Journal article
Molecular cloning and sequence of porcine interleukin 6 cDNA and expression of mRNA in synovial fibroblasts in vitro
Abstract
Synovial fibroblasts, derived from enzyme digestion of porcine synovial tissue, released interleukin 6 (IL-6) bioactivity in culture and this release was enhanced by IL-1 alpha. The porcine IL-6 was cloned from a cDNA library made from these cells using human IL-6 cDNA as a probe. Clone PIL-6[13-8] was sequenced and coded for 212 amino acids with 62% homology and 42% homology to published sequences of human and mouse (or rat), respectively. The …
Authors
Richards CD; Saklatvala J
Journal
Cytokine, Vol. 3, No. 4, pp. 269–276
Publisher
Elsevier
Publication Date
July 1991
DOI
10.1016/1043-4666(91)90494-x
ISSN
1043-4666