Matthew S Miller - McMaster Experts

Affiliations

Faculty of Health Sciences, McMaster University
Member, McMaster Immunology Research Centre (MIRC), Faculty of Health Sciences
Member, Michael G. DeGroote Institute for Infectious Disease Research (IIDR), Faculty of Health Sciences
Associate Professor, Biochemistry & Biomedical Sciences, Faculty of Health Sciences
Assistant Dean, Biochemistry Graduate Program, McMaster University,

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selected scholarly activity

conferences
- Antibody idiotype plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity (ADCC) against influenza A virus. Journal of Immunology. 78.15-78.15. 2016
- Fc-dependent effector functions of neutrophils induced by hemagglutinin stalk-specific antibodies. Journal of Immunology. 146.17-146.17. 2016
- Effects of Soy Protein Isolate and/or Omega-3 Polyunsaturated Fatty Acid Supplementation on Bone Health in Female Rats with Polycystic Kidney Disease. The FASEB Journal. 2013
journal articles
- LPS-induced lung tissue-resident trained innate immunity provides differential protection against pneumococci and SARS-CoV-2.. Cell Reports. 43:114849. 2024
- A case report of primary pericardial sarcoma.. European Heart Journal - Case Reports. 8:ytae284. 2024
- High‐Precision Viral Detection Using Electrochemical Kinetic Profiling of Aptamer‐Antigen Recognition in Clinical Samples and Machine Learning. Angewandte Chemie International Edition. 63:e202400413. 2024
- High‐Precision Viral Detection Using Electrochemical Kinetic Profiling of Aptamer‐Antigen Recognition in Clinical Samples and Machine Learning. Angewandte Chemie International Edition. 136. 2024
- Application of MALDI-TOF MS and machine learning for the detection of SARS-CoV-2 and non-SARS-CoV-2 respiratory infections. Microbiology spectrum. 12:e0406823. 2024
- Examining the Association between Frailty and Antibody Neutralization of SARS-CoV-2: A Multisite Retrospective Cohort Study. Journal of the American Medical Directors Association. 25:647-649.e8. 2024
- Mucosal correlates of protection after influenza viral challenge of vaccinated and unvaccinated healthy volunteers. mBio. 15:e0237223. 2024
- Risk factors for recognized and unrecognized SARS-CoV-2 infection: a seroepidemiologic analysis of the Prospective Urban Rural Epidemiology (PURE) study. Microbiology spectrum. 12:e0149223. 2024
- Contribution of immunoglobulin products in influencing seasonal influenza infection and severity in antibody immune deficiency patients receiving immunoglobulin replacement therapy.. Frontiers in Immunology. 15:1452106. 2024
- Immunomodulatory drugs have divergent effects on humoral and cellular immune responses to SARS-CoV-2 vaccination in people living with rheumatoid arthritis. Scientific Reports. 13:22846. 2023
- ASK1 inhibitors are potential pan-antiviral drugs, which dampen replication of diverse viruses including SARS-CoV2. Antiviral Research. 220:105736-105736. 2023
- Early humoral and cellular responses after bivalent SARS‐CoV‐2 mRNA‐1273.214 vaccination in long‐term care and retirement home residents in Ontario, Canada: An observational cohort study. Journal of Medical Virology. 95:e29170. 2023
- Early Omicron infection is associated with increased reinfection risk in older adults in long-term care and retirement facilities. EClinicalMedicine. 63:102148-102148. 2023
- Sensitivity to Neutralizing Antibodies and Resistance to Type I Interferons in SARS-CoV-2 R.1 Lineage Variants, Canada. Emerging Infectious Diseases. 29:1386-1396. 2023
- Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection. Nature Reviews Immunology. 23:381-396. 2023
- Targeting the MR1-MAIT cell axis improves vaccine efficacy and affords protection against viral pathogens. PLoS Pathogens. 19:e1011485-e1011485. 2023
- SG-APSIC1054: Sputnik-V postvaccination immunologic responses in nasal mucosa: A prospective cohort study in Kazakhstan. Antimicrobial Stewardship and Healthcare Epidemiology. 3:s4-s4. 2023
- Comparison of three dosing intervals for the primary vaccination of the SARS-CoV-2 mRNA Vaccine (BNT162b2) on magnitude, neutralization capacity and durability of the humoral immune response in health care workers: A prospective cohort study. PLoS ONE. 18:e0281673-e0281673. 2023
- Corrigendum: Differential biodistribution of adenoviral-vectored vaccine following intranasal and endotracheal deliveries leads to different immune outcomes. Frontiers in Immunology. 14:1151809. 2023
- Right atrial structural remodeling predict worse outcomes in transcatheter mitral valve repair.. Catheterization and Cardiovascular Interventions. 101:217-224. 2023
- The impact of Gam-COVID-Vac, an Adv5/Adv26 COVID-19 vaccine, on the biomarkers of endothelial function, coagulation and platelet activation. PLoS ONE. 18:e0293074-e0293074. 2023
- Three on Three: Universal and High-Affinity Molecular Recognition of the Symmetric Homotrimeric Spike Protein of SARS-CoV-2 with a Symmetric Homotrimeric Aptamer. Journal of the American Chemical Society. 144:23465-23473. 2022
- Cytomegalovirus Seropositivity in Older Adults Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination. Journal of Immunology. 209:1892-1905. 2022
- Cytomegalovirus Seropositivity in Older Adults Changes the T Cell Repertoire but Does Not Prevent Antibody or Cellular Responses to SARS-CoV-2 Vaccination.. Journal of Immunology. 209:1892-1905. 2022
- Sustained Delivery of a Monoclonal Antibody against SARS-CoV-2 by Microencapsulated Cells: A Proof-of-Concept Study. Pharmaceutics. 14:2042-2042. 2022
- Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission. eLife. 11:e77779. 2022
- Decavanadate interactions with the elements of the SARS-CoV-2 spike protein highlight the potential role of electrostatics in disrupting the infectivity cycle. Journal of Inorganic Biochemistry. 234:111899-111899. 2022
- Protocol for isolation and characterization of lung tissue resident memory T cells and airway trained innate immunity after intranasal vaccination in mice. STAR Protocols. 3:101652-101652. 2022
- Cigarette smoke augments CSF3 expression in neutrophils to compromise alveolar–capillary barrier function during influenza infection. European Respiratory Journal. 60:2102049-2102049. 2022
- Hemagglutinin stalk-binding antibodies enhance effectiveness of neuraminidase inhibitors against influenza via Fc-dependent effector functions. Cell Reports Medicine. 3:100718-100718. 2022
- Sputnik-V reactogenicity and immunogenicity in the blood and mucosa: a prospective cohort study. Scientific Reports. 12:13207. 2022
- Probe design for simultaneous, targeted capture of diverse metagenomic targets. Cell Reports Methods. 2:100246-100246. 2022
- Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection. PLoS Pathogens. 18:e1010471-e1010471. 2022
- Adenovirus 5 Vectors Expressing SARS-CoV-2 Proteins. Clinical and Vaccine Immunology. 7:e0099821. 2022
- A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern. Chemistry - A European Journal. 28:e202200078. 2022
- A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern. Chemistry - A European Journal. 28:e202200524. 2022
- Front Cover: A Universal DNA Aptamer that Recognizes Spike Proteins of Diverse SARS‐CoV‐2 Variants of Concern (Chem. Eur. J. 15/2022). Chemistry - A European Journal. 28:e202200523. 2022
- Antibody Responses to Third-Dose mRNA Vaccines in Nursing Home and Assisted Living Residents. Journal of the American Medical Directors Association. 23:444-446. 2022
- Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2. Cell. 185:896-915.e19. 2022
- Inactivated and live-attenuated seasonal influenza vaccines boost broadly neutralizing antibodies in children. Cell Reports Medicine. 3:100509-100509. 2022
- Differential Biodistribution of Adenoviral-Vectored Vaccine Following Intranasal and Endotracheal Deliveries Leads to Different Immune Outcomes. Frontiers in Immunology. 13:860399. 2022
- Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice. Molecular Metabolism. 55:101404-101404. 2022
- High SARS-CoV-2 seroprevalence in Karaganda, Kazakhstan before the launch of COVID-19 vaccination. PLoS ONE. 17:e0272008-e0272008. 2022
- Increased left and right atrial volume indices are associated with decreased survival times post-cardiac arrest.. Resuscitation. 170:306-313. 2022
- Antibody Responses to 3^rd Dose mRNA Vaccines in Nursing Home and Assisted Living Residents 2021
- Antibody Responses 3-5 Months Post-Vaccination with mRNA-1273 or BNT163b2 in Nursing Home Residents. Journal of the American Medical Directors Association. 22:2512-2514. 2021
- Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections. Viruses. 13:2239-2239. 2021
- High‐Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild‐Type and B.1.1.7 SARS‐CoV‐2 in Unprocessed Saliva. Angewandte Chemie International Edition. 60:24266-24274. 2021
- High‐Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild‐Type and B.1.1.7 SARS‐CoV‐2 in Unprocessed Saliva. Angewandte Chemie International Edition. 133:24468-24476. 2021
- Effect of inactivated influenza vaccination on human coronavirus infection: Secondary analysis of a randomized trial in Hutterite colonies. Vaccine. 39:7058-7065. 2021
- Robust Evaluation of Ultraviolet-C Sensitivity for SARS-CoV-2 and Surrogate Coronaviruses. Microbiology spectrum. 9:e0053721. 2021
- Potentiation of long-acting β2-agonist and glucocorticoid responses in human airway epithelial cells by modulation of intracellular cAMP. Respiratory Research. 22:266. 2021
- Probe design for simultaneous, targeted capture of diverse metagenomic targets. Cell Reports Methods. 1:100069-100069. 2021
- Cigarette smoke exposure attenuates the induction of antigen-specific IgA in the murine upper respiratory tract. Mucosal Immunology. 14:1067-1076. 2021
- Antibody Responses 3-5 Months Post-Vaccination with mRNA-1273 or BNT163b2 in Nursing Home Residents 2021
- Effects of repeated vaccination and vaccine formulation on the induction of broadly neutralizing antibody responses against influenza A virus in children 2021
- Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library. Nucleic Acids Research (NAR). 49:7267-7279. 2021
- Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice 2021
- IgA potentiates NETosis in response to viral infection. Proceedings of the National Academy of Sciences of the United States of America. 118:e2101497118. 2021
- Neutrophils and Influenza: A Thin Line between Helpful and Harmful. Vaccines. 9:597-597. 2021
- A liposome-displayed hemagglutinin vaccine platform protects mice and ferrets from heterologous influenza virus challenge. Proceedings of the National Academy of Sciences of the United States of America. 118:e2025759118. 2021
- Covalent Stabilization of Antibody Recruitment Enhances Immune Recognition of Cancer Targets. Biochemistry. 60:1447-1458. 2021
- Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses. iScience. 24:102477-102477. 2021
- Characteristics of Anti-SARS-CoV-2 Antibodies in Recovered COVID-19 Subjects. Viruses. 13:697-697. 2021
- Engineered Nanoparticle Applications for Recombinant Influenza Vaccines. Molecular Pharmaceutics. 18:576-592. 2021
- Predicting the recombination potential of severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome coronavirus. Journal of General Virology. 101:1251-1260. 2020
- Potentiation of Long-Acting β₂-Agonist and Glucocorticoid Responses in Human Airway Epithelial Cells by Modulation of Intracellular cAMP 2020
- Association between vitamin D metabolites, vitamin D binding protein, and proteinuria in dogs.. Journal of Veterinary Internal Medicine (JVIM). 34:2468-2477. 2020
- Age-Specific Incidence of Influenza A Responds to Change in Virus Subtype Dominance. Clinical Infectious Diseases. 71:e195-e198. 2020
- Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike. Cell Reports Medicine. 1:100126-100126. 2020
- Immunological considerations for COVID-19 vaccine strategies. Nature Reviews Immunology. 20:615-632. 2020
- Bat Influenza Viruses: Making a Double Agent of MHC Class II. Trends in Microbiology. 28:703-706. 2020
- Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue. European Respiratory Journal. 56:2001123-2001123. 2020
- Isolation, Sequence, Infectivity, and Replication Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2. Emerging Infectious Diseases. 26:2054-2063. 2020
- Repeated Seasonal Influenza Vaccination: How Much Is Too Much of a Good Thing?. Journal of Infectious Diseases. 222:173-175. 2020
- Rapid Design of a Bait Capture Platform for Culture- and Amplification-Free Next-Generation Sequencing of SARS-CoV-2 2020
- Correction to: Determinants of Influenza Mortality Trends: Age-Period-Cohort Analysis of Influenza Mortality in the United States, 1959–2016. Demography. 2019
- Determinants of Influenza Mortality Trends: Age-Period-Cohort Analysis of Influenza Mortality in the United States, 1959–2016. Demography. 56:1723-1746. 2019
- Comparative Immunogenicity of the 2014–2015 Northern Hemisphere Trivalent IIV and LAIV against Influenza A Viruses in Children. Vaccines. 7:87-87. 2019
- Thermal Stabilization of Viral Vaccines in Low-Cost Sugar Films. Scientific Reports. 9:7631. 2019
- Excipient selection for thermally stable enveloped and non-enveloped viral vaccine platforms in dry powders. International Journal of Pharmaceutics. 561:66-73. 2019
- Original Antigenic Sin: How First Exposure Shapes Lifelong Anti–Influenza Virus Immune Responses. Journal of Immunology. 202:335-340. 2019
- Reporting and evaluating influenza virus surveillance data: An argument for incidence by single year of age. Vaccine. 36:6249-6252. 2018
- Reviewing the evidence for viruses as environmental risk factors for ALS: A new perspective. Cytokine. 108:173-178. 2018
- “Gnothi Seauton”: Leveraging the Host Response to Improve Influenza Virus Vaccine Efficacy. Vaccines. 6:23-23. 2018
- Pandemic Paradox: Early Life H2N2 Pandemic Influenza Infection Enhanced Susceptibility to Death during the 2009 H1N1 Pandemic. mBio. 9:e02091-e02017. 2018
- Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice. Nature Communications. 8:846. 2017
- Regulation of kynurenine biosynthesis during influenza virus infection. The FEBS Journal. 284:222-236. 2017
- Abnormal regulation of the antiviral response in neurological/neurodegenerative diseases. Cytokine. 88:251-258. 2016
- Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner. mBio. 7:e01624-e01616. 2016
- Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus. Proceedings of the National Academy of Sciences of the United States of America. 113:11931-11936. 2016
- Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact. Proceedings of the National Academy of Sciences of the United States of America. 113:E5944-E5951. 2016
- Autoimmune VariantPTPN22C1858T Is Associated With Impaired Responses to Influenza Vaccination. Journal of Infectious Diseases. 214:248-257. 2016
- Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets. Journal of Virology. 90:3268-3273. 2016
- CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection. Cell Reports. 14:2389-2401. 2016
- Measuring the neutralization potency of influenza A virus hemagglutinin stalk/stem-binding antibodies in polyclonal preparations by microneutralization assay. ImmunoMethods. 90:95-100. 2015
- Age-dependent immune responses and immune protection after avian coronavirus vaccination. Vaccine. 33:2655-2661. 2015
- Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis. Nature Immunology. 16:485-494. 2015
- Broadly Neutralizing Anti-Influenza Virus Antibodies: Enhancement of Neutralizing Potency in Polyclonal Mixtures and IgA Backbones. Journal of Virology. 89:3610-3618. 2015
- Is Antigenic Sin Always “Original?” Re-examining the Evidence Regarding Circulation of a Human H1 Influenza Virus Immediately Prior to the 1918 Spanish Flu. PLoS Pathogens. 11:e1004615-e1004615. 2015
- Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans. Proceedings of the National Academy of Sciences of the United States of America. 111:13133-13138. 2014
- Peering into the Crystal Ball: Influenza Pandemics and Vaccine Efficacy. Cell. 157:294-299. 2014
- Assessment of Influenza Virus Hemagglutinin Stalk-Based Immunity in Ferrets. Journal of Virology. 88:3432-3442. 2014
- Neutralizing Antibodies Against Previously Encountered Influenza Virus Strains Increase over Time: A Longitudinal Analysis. Science Translational Medicine. 5:198ra107. 2013
- Serum- and Glucocorticoid-Regulated Kinase 1 Is Required for Nuclear Export of the Ribonucleoprotein of Influenza A Virus. Journal of Virology. 87:6020-6026. 2013
- 1976 and 2009 H1N1 Influenza Virus Vaccines Boost Anti-Hemagglutinin Stalk Antibodies in Humans. Journal of Infectious Diseases. 207:98-105. 2013
- Age-Specific Mortality During the 1918 Influenza Pandemic: Unravelling the Mystery of High Young Adult Mortality. PLoS ONE. 8:e69586-e69586. 2013
- Comparative toxicokinetics of low-viscosity mineral oil in Fischer 344 rats, Sprague-Dawley rats, and humans--implications for an Acceptable Daily Intake (ADI).. Regulatory Toxicology and Pharmacology. 63:69-77. 2012
- Characterization of the 55-Residue Protein Encoded by the 9S E1A mRNA of Species C Adenovirus. Journal of Virology. 86:4222-4233. 2012
- Edge Colored Hypergraphic Arrangements. Pure and Applied Mathematics Quarterly. 8:757-779. 2012
- Adenovirus E1A Directly Targets the E2F/DP-1 Complex. Journal of Virology. 85:8841-8851. 2011
- An Unhealthy Relationship: Viral Manipulation of the Nuclear Receptor Superfamily. Future Microbiology. 6:999-1019. 2011
- RASCAL Is a New Human Cytomegalovirus-Encoded Protein That Localizes to the Nuclear Lamina and in Cytoplasmic Vesicles at Late Times Postinfection. Journal of Virology. 84:6483-6496. 2010
- Onset of Human Cytomegalovirus Replication in Fibroblasts Requires the Presence of an Intact Vimentin Cytoskeleton. Journal of Virology. 83:7015-7028. 2009
- Human cytomegalovirus US9 protein contains an N-terminal signal sequence and a C-terminal mitochondrial localization domain, and does not alter cellular sensitivity to apoptosis. Journal of General Virology. 90:1172-1182. 2009
- Cardiopulmonary disease in the geriatric dog and cat.. Veterinary Clinics of North America - Small Animal Practice. 19:87-102. 1989
preprints