Does Substitution of T4 with T3 Plus T4 for T4 Replacement Improve Depressive Symptoms in Patients with Hypothyroidism?
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Substitution of T4 with T3 for T4 replacement in patients with hypothyroidism was undertaken using a randomized placebo controlled study design. Forty individuals were included who had depressive symptoms on stable doses of levothyroxine. Combined T4 plus T3 did not have a significantly different effect on mood and well-being scores than did T4 alone.
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