Lesley MacNeil - McMaster Experts

Affiliations

McMaster University,
Faculty of Health Sciences, McMaster University
Member, Michael G. DeGroote Institute for Infectious Disease Research (IIDR), Faculty of Health Sciences
Associate Professor, Biochemistry & Biomedical Sciences, Faculty of Health Sciences
Member, Farncombe Family Digestive Health Research Institute, Faculty of Health Sciences

Scholarly Activity in McMaster Experts

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selected scholarly activity

conferences
- Supervised and semi-supervised methods of nematode images classification for drug discovery. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 129301r-129301r-6. 2024
- TriCC: Self-Supervised Contrastive Learning for Image-Based Antiparasitic Drug Discovery. Proceedings - International Symposium on Biomedical Imaging. 1-5. 2024
- Simple, straight-path growth cone migrations are regulated by more than a guidance cue gradient and attractive or repulsive receptors for the cue. Mechanisms of Development. S14-S14. 2005
journal articles
- SHC-3: a previously unidentified C. elegans Shc family member functions in the insulin-like signaling pathway to enhance survival during L1 arrest. Genetics. 228:iyae093. 2024
- Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies. Molecular Neurodegeneration. 18:82. 2023
- Lessons from assembling a microbial natural product and pre-fractionated extract library in an academic laboratory. Journal of Industrial Microbiology and Biotechnology. 50:kuad042. 2023
- Editorial: C. elegans MAPS the way: the 2022 C. elegans meeting on metabolism, aging, pathogenesis, and stress (MAPS 2022). Frontiers in Physiology. 14:1331912. 2023
- Microbiomes: How a gut bacterium promotes healthier living in a nematode. Current Biology. 32:R428-R430. 2022
- Cuticle Collagen Expression Is Regulated in Response to Environmental Stimuli by the GATA Transcription Factor ELT-3 inCaenorhabditis elegans. Genetics. 215:483-495. 2020
- Nutrient Sensing and Response Drive Developmental Progression in Caenorhabditis elegans. BioEssays. 42:e1900194. 2020
- Bacteria transmit metformin-associated lifespan extension. Nature Reviews Endocrinology. 16:9-10. 2020
- Biology is the root of variability: cautionary tales in Caenorhabditis elegans biology. Biochemical Society Transactions. 47:887-896. 2019
- The Caenorhabditis elegans Oxidative Stress Response Requires the NHR-49 Transcription Factor. G3: Genes, Genomes, Genetics. 8:3857-3863. 2018
- wrt-2 expression oscillates during larval development.. microPublication Biology. 2018:10.17912/4bw7-10.17912/ep56. 2018
- Pseudomonas aeruginosa type IV minor pilins and PilY1 regulate virulence by modulating FimS-AlgR activity. PLoS Pathogens. 14:e1007074-e1007074. 2018
- Transformation of the Anticancer Drug Doxorubicin in the Human Gut Microbiome. ACS Infectious Diseases. 4:68-76. 2018
- Pseudomonas aeruginosatype IV minor pilins and PilY1 regulate virulence by modulating FimS-AlgR activity 2017
- The Oxidative Stress Response in Caenorhabditis elegans Requires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2. Genetics. 206:1909-1922. 2017
- Packing on the Pounds in Response to Bacterial Growth Conditions. Developmental Cell. 41:335-336. 2017
- Integrative Physiology: At the Crossroads of Nutrition, Microbiota, Animal Physiology, and Human Health. Cell Metabolism. 25:522-534. 2017
- Transcription Factor Activity Mapping of a Tissue-Specific In Vivo Gene Regulatory Network. Cell Systems. 1:152-162. 2015
- RNA Interference inCaenorhabditis elegans. Current Protocols in Molecular Biology. 109:26.3.1-26.3.30. 2015
- Transcriptional regulation of Caenorhabditis elegansFOXO/DAF-16 modulates lifespan. Longevity and Healthspan. 3:5. 2014
- Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits. Cell. 156:1336-1337. 2014
- Interspecies Systems Biology Uncovers Metabolites Affecting C. elegans Gene Expression and Life History Traits. Cell. 156:759-770. 2014
- Food, pathogen, signal. Worm. 2:e26454-e26454. 2013
- Integration of Metabolic and Gene Regulatory Networks Modulates the C. elegans Dietary Response. Cell. 153:1406-1407. 2013
- Diet-Induced Developmental Acceleration Independent of TOR and Insulin in C. elegans. Cell. 153:240-252. 2013
- Integration of Metabolic and Gene Regulatory Networks Modulates the C. elegans Dietary Response. Cell. 153:253-266. 2013
- Gene regulatory networks and the role of robustness and stochasticity in the control of gene expression. Genome Research. 21:999-999. 2011
- Gene regulatory networks and the role of robustness and stochasticity in the control of gene expression. Genome Research. 21:645-657. 2011
- Erratum: Gene regulatory networks and the role of robustness and stochasticity in the control of gene expression (Genome Research (2011) 21, (645-657) DOI: 10.1101/gr.097378.109). Genome Research. 21:999. 2011
- Genetic association of the GDNF alpha-receptor genes with schizophrenia and clozapine response. Journal of Psychiatric Research. 44:700-706. 2010
- Caenorhabditis elegans SMA-10/LRIG Is a Conserved Transmembrane Protein that Enhances Bone Morphogenetic Protein Signaling. PLoS Genetics. 6:e1000963-e1000963. 2010
- Erratum: Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nature Genetics. 42:361-361. 2010
- Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network. Molecular Systems Biology. 6:367. 2010
- Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nature Genetics. 41:1295-1302. 2009
- UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways. Nature Neuroscience. 12:150-155. 2009
- The Pea3 Ets transcription factor regulates differentiation of multipotent progenitor cells during mammary gland development. Developmental Biology. 325:106-121. 2009
- Glypican LON-2 Is a Conserved Negative Regulator of BMP-like Signaling in Caenorhabditis elegans. Current Biology. 17:159-164. 2007
- [ST6]: UNC‐129 acts in the UNC‐5/UNC‐6 pathway to regulate axon guidance. International Journal of Developmental Neuroscience. 24:490-491. 2006
other
- The Role of PEA3 in Mammary Gland Development and Tumorigenesis 1999
preprints
theses
- EFFECTS OF THE NEXT GENERATION PROBIOTIC, AKKERMANSIA MUCINIPHILA, ON INTESTINAL INFLAMMATION AND BARRIER FUNCTION. Gastroenterology. 2023