Journal article
The Oxidative Stress Response in Caenorhabditis elegans Requires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2
Abstract
Cellular damage caused by reactive oxygen species is believed to be a major contributor to age-associated diseases. Previously, we characterized the Caenorhabditis elegans Brap2 ortholog (BRAP-2) and found that it is required to prevent larval arrest in response to elevated levels of oxidative stress. Here, we report that C. elegans brap-2 mutants display increased expression of SKN-1-dependent, phase II detoxification enzymes that is dependent …
Authors
Hu Q; D’Amora DR; MacNeil LT; Walhout AJM; Kubiseski TJ
Journal
Genetics, Vol. 206, No. 4, pp. 1909–1922
Publisher
Oxford University Press (OUP)
Publication Date
August 1, 2017
DOI
10.1534/genetics.116.198788
ISSN
0016-6731