Journal article
Cerebral Metabolism of 6–[18F]Fluoro‐l‐3,4‐Dihydroxyphenylalanine in the Primate
Abstract
The tracers 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine (6-[18F]fluoro-L-DOPA) and L-[14C]DOPA were injected simultaneously into rhesus monkeys, and the time course of their metabolites was measured in the striatum and in the occipital and frontal cortices. In the striatum, 6-[18F]fluoro-L-DOPA was metabolized to 6-[18F]fluorodopamine, 3,4-dihydroxy-6-[18F]fluorophenylacetic acid, and 6-[18F]fluorohomovanillic acid. The metabolite pattern was …
Authors
Firnau G; Sood S; Chirakal R; Nahmias C; Garnett ES
Journal
Journal of Neurochemistry, Vol. 48, No. 4, pp. 1077–1082
Publisher
Wiley
Publication Date
April 1987
DOI
10.1111/j.1471-4159.1987.tb05629.x
ISSN
0022-3042