Journal article
Cerebrospinal fluid from patients with amyotrophic lateral sclerosis inhibits sonic hedgehog function
Abstract
Sonic hedgehog (Shh) is a morphogen essential to the developing nervous system that continues to play an important role in adult life by contributing to cell proliferation and differentiation, maintaining blood-brain barrier integrity, and being cytoprotective against oxidative and excitotoxic stress, all features of importance in amyotrophic lateral sclerosis (ALS). ALS is a fatal disease characterized by selective loss of motor neurons due to …
Authors
Drannik A; Martin J; Peterson R; Ma X; Jiang F; Turnbull J
Journal
PLOS ONE, Vol. 12, No. 2,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pone.0171668
ISSN
1932-6203