Journal article
Low-dose combination therapy with rosiglitazone and metformin to prevent type 2 diabetes mellitus (CANOE trial): a double-blind randomised controlled study
Abstract
BACKGROUND: The evolving epidemic of type 2 diabetes has challenged health-care providers to assess the safety and efficacy of various diabetes prevention strategies. The CANOE (CAnadian Normoglycemia Outcomes Evaluation) trial investigated whether low-dose combination therapy would affect development of type 2 diabetes.
METHODS: In this double-blind, randomised controlled trial undertaken in clinics in Canadian centres, 207 patients with …
Authors
Zinman B; Harris SB; Neuman J; Gerstein HC; Retnakaran RR; Raboud J; Qi Y; Hanley AJ
Journal
The Lancet, Vol. 376, No. 9735, pp. 103–111
Publisher
Elsevier
Publication Date
July 2010
DOI
10.1016/s0140-6736(10)60746-5
ISSN
0140-6736