Journal article
Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator
Abstract
Bcl-2 family protein including anti-apoptotic (Bcl-2) or pro-apoptotic (Bax) members can form ion channels when incorporated into synthetic lipid bilayers. This contrasts with the observation that Bcl-2 stabilizes the mitochondrial membrane barrier function and inhibits the permeability transition pore complex (PTPC). Here we provide experimental data which may explain this apparent paradox. Bax and adenine nucleotide translocator (ANT), the …
Authors
Brenner C; Cadiou H; Vieira HL; Zamzami N; Marzo I; Xie Z; Leber B; Andrews D; Duclohier H; Reed JC
Journal
Oncogene, Vol. 19, No. 3, pp. 329–336
Publisher
Springer Nature
Publication Date
January 20, 2000
DOI
10.1038/sj.onc.1203298
ISSN
0950-9232