Journal article
The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation
Abstract
A new mechanism by which acute myeloid leukaemia patients become resistant to Ara-C and a newer treatment, ribavirin, is uncovered; these drugs can be glucuronidated and thereby inactivated by members of the UDP glucuronosyltransferase family of enzymes activated through GLI1 signalling.
Authors
Zahreddine HA; Culjkovic-Kraljacic B; Assouline S; Gendron P; Romeo AA; Morris SJ; Cormack G; Jaquith JB; Cerchietti L; Cocolakis E
Journal
Nature, Vol. 511, No. 7507, pp. 90–93
Publisher
Springer Nature
Publication Date
July 3, 2014
DOI
10.1038/nature13283
ISSN
0028-0836