Journal article
Human malignant melanoma cells express high-affinity receptors for melatonin: antiproliferative effects of melatonin and 6-chloromelatonin
Abstract
In order to explore the potential oncostatic properties of the pineal hormone, melatonin, we have investigated its binding characteristics and functional effects in a human malignant melanoma (M-6) cell line. Binding studies in M-6 membranes showed the coexistence of 2-[125I]iodomelatonin binding sites with picomolar and nanomolar affinities. Guanine nucleotides caused conversion of all high-affinity sites to a low-affinity state without a …
Authors
Ying S-W; Niles LP; Crocker C
Journal
European Journal of Pharmacology, Vol. 246, No. 2, pp. 89–96
Publisher
Elsevier
Publication Date
July 1993
DOI
10.1016/0922-4106(93)90084-m
ISSN
0014-2999