Journal article
G-Protein–Coupled Receptors as Signaling Targets for Antiplatelet Therapy
Abstract
Platelet G protein-coupled receptors (GPCRs) initiate and reinforce platelet activation and thrombus formation. The clinical utility of antagonists of the P2Y(12) receptor for ADP suggests that other GPCRs and their intracellular signaling pathways may represent viable targets for novel antiplatelet agents. For example, thrombin stimulation of platelets is mediated by 2 protease-activated receptors (PARs), PAR-1 and PAR-4. Signaling downstream …
Authors
Smyth SS; Woulfe DS; Weitz JI; Gachet C; Conley PB; Goodman SG; Roe MT; Kuliopulos A; Moliterno DJ; French PA
Journal
Arteriosclerosis Thrombosis and Vascular Biology, Vol. 29, No. 4, pp. 449–457
Publisher
Wolters Kluwer
Publication Date
4 2009
DOI
10.1161/atvbaha.108.176388
ISSN
1079-5642