Journal article
Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania
Abstract
Cannabidiol (CBD), a Cannabis sativa constituent, may present a pharmacological profile similar to mood stabilizing drugs, in addition to anti-oxidative and neuroprotective properties. The present study aims to directly investigate the effects of CBD in an animal model of mania induced by D-amphetamine (D-AMPH). In the first model (reversal treatment), rats received saline or D-AMPH (2 mg/kg) once daily intraperitoneal (i.p.) for 14 days, and …
Authors
Valvassori SS; Elias G; de Souza B; Petronilho F; Dal-Pizzol F; Kapczinski F; Trzesniak C; Tumas V; Dursun S; Chagas MHN
Journal
Journal of Psychopharmacology, Vol. 25, No. 2, pp. 274–280
Publisher
SAGE Publications
Publication Date
February 2011
DOI
10.1177/0269881109106925
ISSN
0269-8811
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AmphetamineAnimalsAntimanic AgentsBipolar DisorderBrain-Derived Neurotrophic FactorCannabidiolCorpus StriatumDisease Models, AnimalDopamine AgentsDose-Response Relationship, DrugDrug Administration ScheduleHippocampusHyperkinesisMaleMotor ActivityOxidative StressPrefrontal CortexProtein CarbonylationRatsRats, Wistar