Journal article
Decreased Satellite Cell Number and Function in Humans and Mice With Type 1 Diabetes Is the Result of Altered Notch Signaling
Abstract
Type 1 diabetes (T1D) negatively influences skeletal muscle health; however, its effect on muscle satellite cells (SCs) remains largely unknown. SCs from samples from rodents (Akita) and human subjects with T1D were examined to discern differences in SC density and functionality compared with samples from their respective control subjects. Examination of the Notch pathway was undertaken to investigate its role in changes to SC functionality. …
Authors
D’Souza DM; Zhou S; Rebalka IA; MacDonald B; Moradi J; Krause MP; Al-Sajee D; Punthakee Z; Tarnopolsky MA; Hawke TJ
Journal
Diabetes, Vol. 65, No. 10, pp. 3053–3061
Publisher
American Diabetes Association
Publication Date
October 1, 2016
DOI
10.2337/db15-1577
ISSN
0012-1797