Journal article
Fetal and Neonatal Nicotine Exposure in Wistar Rats Causes Progressive Pancreatic Mitochondrial Damage and Beta Cell Dysfunction
Abstract
Nicotine replacement therapy (NRT) is currently recommended as a safe smoking cessation aid for pregnant women. However, fetal and neonatal nicotine exposure in rats causes mitochondrial-mediated beta cell apoptosis at weaning, and adult-onset dysglycemia, which we hypothesize is related to progressive mitochondrial dysfunction in the pancreas. Therefore in this study we examined the effect of fetal and neonatal exposure to nicotine on …
Authors
Bruin JE; Petre MA; Raha S; Morrison KM; Gerstein HC; Holloway AC
Journal
PLOS ONE, Vol. 3, No. 10,
Publisher
Public Library of Science (PLoS)
Publication Date
2008
DOI
10.1371/journal.pone.0003371
ISSN
1932-6203