Journal article
A Multicenter Observational Study of Incretin-based Drugs and Heart Failure
Abstract
BACKGROUND: There is concern that antidiabetic incretin-based drugs, including dipeptidyl peptidase 4 (DPP-4) inhibitors and glucagon-like peptide 1 (GLP-1) analogues, can increase the risk of heart failure. Ongoing clinical trials may not have large enough samples to effectively address this issue.
METHODS: We applied a common protocol in the analysis of multiple cohorts of patients with diabetes. We used health care data from four Canadian …
Authors
Filion KB; Azoulay L; Platt RW; Dahl M; Dormuth CR; Clemens KK; Hu N; Paterson JM; Targownik L; Turin TC
Journal
New England Journal of Medicine, Vol. 374, No. 12, pp. 1145–1154
Publisher
Massachusetts Medical Society
Publication Date
March 24, 2016
DOI
10.1056/nejmoa1506115
ISSN
0028-4793