Journal article
A Small Molecule Discrimination Map of the Antibiotic Resistance Kinome
Abstract
Kinase-mediated resistance to antibiotics is a significant clinical challenge. These enzymes share a common protein fold characteristic of Ser/Thr/Tyr protein kinases. We screened 14 antibiotic resistance kinases against 80 chemically diverse protein kinase inhibitors to map resistance kinase chemical space. The screens identified molecules with both broad and narrow inhibition profiles, proving that protein kinase inhibitors offer privileged …
Authors
Shakya T; Stogios PJ; Waglechner N; Evdokimova E; Ejim L; Blanchard JE; McArthur AG; Savchenko A; Wright GD
Journal
Cell Chemical Biology, Vol. 18, No. 12, pp. 1591–1601
Publisher
Elsevier
Publication Date
December 2011
DOI
10.1016/j.chembiol.2011.10.018
ISSN
2451-9456