Journal article
Effects of inhaled ciclesonide on circulating T‐helper type 1/T‐helper type 2 cells in atopic asthmatics after allergen challenge
Abstract
BACKGROUND: The predominance of T-helper type 2 (Th2) lymphocytes is thought to underlie the pathogenesis of asthma. Allergen inhalation challenge in atopic asthmatic subjects is associated with decreased interferon-gamma (IFN-gamma) positive CD4+ and CD8+ lymphocytes in peripheral blood and induced sputum.
OBJECTIVE: This study examined the effects of an inhaled corticosteroid on these previously described allergen-induced changes in …
Authors
Kawayama T; O'Byrne PM; Watson RM; Killian KJ; Duong M; Yoshida M; Gauvreau GM
Journal
Clinical & Experimental Allergy, Vol. 36, No. 11, pp. 1417–1424
Publisher
Wiley
Publication Date
November 2006
DOI
10.1111/j.1365-2222.2006.02592.x
ISSN
0954-7894
Associated Experts
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Administration, InhalationAdultAllergensAnalysis of VarianceAsthmaBiomarkersBronchial Provocation TestsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCross-Over StudiesDouble-Blind MethodDrug Administration ScheduleEosinophilsFemaleFlow CytometryGlucocorticoidsHumansHypersensitivityInterferon-gammaInterleukin-4Lymphocyte CountMaleMethacholine ChloridePregnenedionesSputum